Director, Large-Scale Manufacturing

This is a standout opportunity for a senior manufacturing leader to take ownership of large-scale drug substance production for a pioneering biopharmaceutical company. With a strong pipeline and a focus on biologics, the organisation is investing heavily in its manufacturing capabilities to meet growing global demand for life-changing therapies.

This position offers both strategic and operational scope, leading multi-disciplinary teams across upstream and downstream manufacturing. The company's mission is to redefine how medicines are made and delivered-balancing speed, quality, and innovation. With a culture rooted in collaboration, continuous improvement, and patient impact, this is a chance to play a key role in shaping the future of biologics manufacturing.

Your role as Director of Large-Scale Manufacturing

• Lead day-to-day operations for large-scale drug substance manufacturing, ensuring safety, quality, and output targets are met.

• Develop and implement long-term strategies to drive efficiency, productivity, and cost-effectiveness across manufacturing processes.

• Oversee all stages of production, from material preparation and cell culture through to bulk drug substance.

• Lead, develop, and mentor cross-functional teams-promoting a culture of innovation, accountability, and high performance.

• Establish KPIs and use data to drive continuous improvement initiatives and operational excellence.

• Set and manage departmental budgets, ensuring optimal use of personnel, materials, and equipment.

• Act as the primary point of contact for internal and external partners on manufacturing-related matters.

• Participate in audits and inspections, ensuring all operations comply with cGMP, FDA, and internal quality standards.

• Collaborate cross-functionally with Quality, Supply Chain, and Technical Services to support commercial and clinical production goals.

• Drive site-wide process innovation by adopting digital tools and lean methodologies.

Experience and qualifications for the Director of Large-Scale Manufacturing role

• 10+ years of leadership experience in biopharmaceutical manufacturing, with strong knowledge of drug substance operations.

• Deep understanding of upstream, downstream, and central services within a GMP-regulated environment.

• Proven ability to lead diverse teams across complex manufacturing operations.

• Strong grasp of regulatory requirements including cGMP and FDA expectations.

• Demonstrated success in managing departmental budgets and driving cost efficiencies.

• Experience leading or participating in inspections and audits.

• Exceptional problem-solving, influencing, and change management skills.

• Bachelor's degree (or equivalent) in life sciences, biochemical/chemical engineering, or related field. Advanced degree preferred.

• Experience implementing Lean Manufacturing or Six Sigma methodologies is a plus.

• Familiarity with digital tools that enhance manufacturing performance is desirable.

Perks and benefits

• Competitive compensation package, including bonus potential and long-term incentives.

• Flexible hybrid working model (minimum 3 days per week onsite).

• Comprehensive health and wellness coverage.

• Generous annual leave and paid holidays.

• Career development support in a culture that values learning and leadership.

• Opportunity to influence the future of biologics manufacturing at scale.

If you're an experienced manufacturing leader looking to make a real impact in the biologics space, apply now for immediate consideration. Alternatively, reach out directly to explore other senior manufacturing opportunities in the life sciences sector.